Original Research

Physiology and pathophysiology of cell organelles

J. J. Theron, N. Claasen, A. Panzer, N. Lizamore
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie | Vol 16, No 1 | a656 | DOI: https://doi.org/10.4102/satnt.v16i1.656 | © 1997 J. J. Theron, N. Claasen, A. Panzer, N. Lizamore | This work is licensed under CC Attribution 4.0
Submitted: 11 July 1997 | Published: 11 July 1997

About the author(s)

J. J. Theron,, South Africa
N. Claasen,, South Africa
A. Panzer,, South Africa
N. Lizamore,, South Africa

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Lysosomes are found in the cytoplasm of all eucaryotic cells except mature red blood cells. The matrix of the organelle is separated from the surrounding cytoplasm by a trilaminar unit membrane and contains a variety of acid hydrolytic enzymes. Morphologically primary (recently formed from the Golgi-complex) are distinguished from secondary lysosomes. The latter type is formed after fusion of a vacuole with a primary lysosome and is ultrastructurally extremely heterogeneous due to the large variety of substrates (macro­ molecules ) incorporated in the matrix of the organelle. The acid hydrolases of lysosomes are divided into the following five groups: phosphatases, nucleases, polysaccharide- and glycosaminoglycans (GAG)-liydrolases, proteases and lipases.


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