Original Research

The blood-brain barrier

H. S. Meij
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie | Vol 10, No 3 | a498 | DOI: https://doi.org/10.4102/satnt.v10i3.498 | © 1991 H. S. Meij | This work is licensed under CC Attribution 4.0
Submitted: 08 July 1991 | Published: 08 July 1991

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H. S. Meij,, South Africa

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Abstract

The composition of the extracellular fluid (ECF) of the brain is of particular importance, because normal functioning of brain cells depends largely upon a chemically stable fluid environment. Changes in the ECF can lead to serious impairment of brain function. The existence of a barrier between the blood and the brain tissue, by means of which a stable surrounding is maintained, was postulated about 80 years ago and we now know that it resides in the continuous layer of endothelium cells of the brain blood capillaries.

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