Original Research

High rates of bacterial vaginosis and Chlamydia in a low-income, high-population-density community in Cape Town

Katie S. Lennard, Smritee Dabee, Shaun L. Barnabas, Enock Havyarimana, Shameem Z. Jaumdally, Gerrit Botha, Nonhlanhla N. Mkhize, Linda-Gail Bekker, Glenda Gray, Nicola Mulder, Jo-Ann Passmore, Heather B. Jaspan
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie | Vol 36, No 1 | a1484 | DOI: https://doi.org/10.4102/satnt.v36i1.1484 | © 2017 Katie S. Lennard, Smritee Dabee, Shaun L. Barnabas, Enock Havyarimana, Shameem Z. Jaumdally, Gerrit Botha, Nonhlanhla N. Mkhize, Linda-Gail Bekker, Glenda Gray, Nicola Mulder, Jo-Ann Passmore, Heather B. Jaspan | This work is licensed under CC Attribution 4.0
Submitted: 09 October 2017 | Published: 12 December 2017

About the author(s)

Katie S. Lennard, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Computational Biology Division, University of Cape Town, South Africa; Department of Integrative Biomedical Sciences, University of Cape Town, South Africa
Smritee Dabee, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Department of Pathology, University of Cape Town, South Africa
Shaun L. Barnabas, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Department of Pathology, University of Cape Town, South Africa
Enock Havyarimana, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Department of Pathology, University of Cape Town, South Africa
Shameem Z. Jaumdally, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Department of Pathology, University of Cape Town, South Africa
Gerrit Botha, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Computational Biology Division, University of Cape Town, South Africa; Department of Integrative Biomedical Sciences, University of Cape Town, South Africa
Nonhlanhla N. Mkhize, National Health Laboratory Service, South Africa
Linda-Gail Bekker, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Desmond Tutu HIV Centre, University of Cape Town, South Africa
Glenda Gray, Perinatal HIV Research Unit, University of the Witwatersrand, South Africa; South African Medical Research Council, South Africa
Nicola Mulder, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Computational Biology Division, University of Cape Town, South Africa; Department of Integrative Biomedical Sciences, University of Cape Town, South Africa
Jo-Ann Passmore, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Department of Pathology, University of Cape Town, South Africa; National Health Laboratory Service, South Africa
Heather B. Jaspan, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Department of Pathology, University of Cape Town, South Africa; Seattle Children’s Research Institute, Department of Pediatrics and Global Health, University of Washington, United States


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Abstract

Young South African women, from resource-poor communities, face several sexual and reproductive health challenges. Here we describe the vaginal microbiota and sexually transmitted infection (STI) prevalence of 102; 16–22-year-old, HIV-negative South African women from a low-income, high-population-density community in Cape Town (CPT). Vaginal microbiota were profiled using 16S rRNA amplicon sequencing; bacterial vaginosis (BV) status was established using Nugent scoring and STIs were determined by multiplex polymerase chain reaction. STIs were common, with 55% of women having at least one STI; 41% were infected with high-risk human papilloma virus (HPV) and a further 28% with low-risk HPV; 44% were infected with Chlamydia, 16% of whom had at least one additional STI. Similarly, BV rates were very high, with 55% of women classified as BV-positive (Nugent score ≥7), 7% as BV-intermediate (Nugent score 3–6) and 38% as BV-negative (Nugent 0–2). Group B Streptococcus (Streptococcus agalactiae), the leading cause of neonatal sepsis, was present in 25% of BV-positive women and 28% of BV-negative women, and was significantly more abundant among BV-negative women. Both Chlamydia infection and BV may adversely affect reproductive health and place these women at additional risk for HIV acquisition. The high abundance of Prevotella amnii, in particular, may increase HIV risk, given its inflammatory capacity. Laboratory-based testing for STIs (Chlamydia and Gonorrhoeae in particular) appear to be warranted in this community, together with further monitoring or treatment of BV.

Research correlation: This article is the original version, of which an Afrikaans translation was made available to provide access to a larger readership, available here: https://doi.org/10.4102/satnt.v36i1.1495


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