pH-regulation: the role of the hepatorenal system

Abstract

The regulation of the acid-base balance is generally regarded as a well entrenched area. However, a number of confusing views on pH-homeostasis, especially with reference to the relationship between the kidney and the ammonium buffer system, appear regularly in textbooks. One reason is that the correct stoichiometry of acid-base regulation is not mentioned. Recently the rote of the liver in pH regulation by controlling the bicarbonate concentration through urea synthesis is proposed. In this paper the role of the liver and kidneys as a team is discussed.