Original Research

The influence of melatonin on the production of free fatty acids by liver tissue in vitro

F. A. Müller, J. M. C. Oosthuizen, I. Reyneke
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie | Vol 8, No 4 | a887 | DOI: https://doi.org/10.4102/satnt.v8i4.887 | © 1989 F. A. Müller, J. M. C. Oosthuizen, I. Reyneke | This work is licensed under CC Attribution 4.0
Submitted: 17 March 1989 | Published: 17 March 1989

About the author(s)

F. A. Müller,, South Africa
J. M. C. Oosthuizen,, South Africa
I. Reyneke,, South Africa

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Abstract

The separate and combined addition of insulin and melatonin to incubated liver slices produced an increase in the free fatty acid concentration in medium after incubation. Compared to insulin the addition of melatonin produced a more dramatic increase in medium free fatty acid concentration. The combined addition of insulin and melatonin have an additive effect on liver tissue in the production of free fatty acids. The increase in the free fatty acid concentration in incubation media is probably caused by stimulation of intracellular lipolysis by melatonin.

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