Original Research

Secretory mechanism of atrial natriuretic peptide (ANP)

J. J. Theron, H. Bosman, R. de Winter, C. N. Henning
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie | Vol 12, No 2 | a557 | DOI: https://doi.org/10.4102/satnt.v12i2.557 | © 1993 J. J. Theron, H. Bosman, R. de Winter, C. N. Henning | This work is licensed under CC Attribution 4.0
Submitted: 09 July 1993 | Published: 09 July 1993

About the author(s)

J. J. Theron,, South Africa
H. Bosman,, South Africa
R. de Winter,, South Africa
C. N. Henning,, South Africa

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Abstract

Mechanical stretch of atrial muscle in vitro induces movement of ANP granules from central perinuclear areas to the periphery of the sarcoplasm at the sarcolemma. This centrifugal movement is associated with maximal secretion of ANP into the suspension medium, without morphological evidence of exocytosis. Since the addition of vinblastine suppresses the movement of granules and ANP secretion, microtubuli are probably involved in the intracellular movement of ANP granules.

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