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In vitro antimicrobial activity and in vitro toxicity of trimethoprim degradation products
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie | Vol 10, No 4 | a505 |
DOI: https://doi.org/10.4102/satnt.v10i4.505
| © 1991 J. J. Bergh, J. C. Breytenbach, S. van Dyk
| This work is licensed under CC Attribution 4.0
Submitted: 08 July 1991 | Published: 08 July 1991
Submitted: 08 July 1991 | Published: 08 July 1991
About the author(s)
J. J. Bergh,, South AfricaJ. C. Breytenbach,, South Africa
S. van Dyk,, South Africa
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Abstract
The in vitro antimicrobial activity and in vitro toxicity of five pyrimidines, degradation products of trimethoprim, was determined. These compounds, formed on hydrolysis or oxidation of the drug, are mostly biologically inactive. With the exception of the ketone, which is active against only one of the micro organisms used in the test, all other compounds are devoid of antimicrobial activity and none possesses acute toxicity or phototoxicity.
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