Original Research

The cardiorespiratory effects of detomidine in the primate (Papio ursinus)

H. Bosman
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie | Vol 9, No 3 | a461 | DOI: https://doi.org/10.4102/satnt.v9i3.461 | © 1990 H. Bosman | This work is licensed under CC Attribution 4.0
Submitted: 05 July 1990 | Published: 08 July 1990

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H. Bosman,, South Africa

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Abstract

Detomidine is a novel imidazole derivative with a high affinity for a₂-adrenoceptors. The cardiorespiratory effects of this drug were evaluated in the primate (Papio ursinus) under ketamine anaesthesia. The release of noradrenalin is modulated by a₂-adrenoceptors, and this resulted in a longer duration of anaesthesia when ketamine was combined with detomidine in comparison with ketamine alone. Detomidine caused a marked bradycardia, which was not reflex induced, but probably the result of a decreased sympathetic outflow. Various conducting disturbances were observed in the electrocardiogram, also probably the result of decreased sympathetic tone to the heart. The effect of detomidine on the respiratory system was minimal. Detomidine proved to be a useful drug to use in combination with ketamine for the induction of anaesthesia in primates. It should, however, not be used during cardiovascular studies.

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