Conference Abstracts

The design and synthesis of a pyrrole-carbaldehyde hit family as HIV-1 integrase inhibitors

Telisha Traut, Raymond Hewer, Judy Coates, D. Bradley G. Williams
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie | Vol 30, No 1 | a268 | DOI: https://doi.org/10.4102/satnt.v30i1.268 | © 2011 Telisha Traut, Raymond Hewer, Judy Coates, D. Bradley G. Williams | This work is licensed under CC Attribution 4.0
Submitted: 07 October 2011 | Published: 26 October 2011

About the author(s)

Telisha Traut, AuTEK Biomed, Advanced Materials Division, Mintek University of Johannesburg, South Africa
Raymond Hewer, AuTEK Biomed, Advanced Materials Division, Mintek, South Africa
Judy Coates, AuTEK Biomed, Advanced Materials Division, Mintek, South Africa
D. Bradley G. Williams, University of Johannesburg, South Africa


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Abstract

Screening of an HIV-1 IN model against database-derived chemical structures identified pyrrole-carbaldehydes as targets for further development. Chemical synthesis using a facile one-pot reaction resulted in the generation of a compound library. Preliminary toxicity and efficacy assays of the water-soluble HCl-salt derivatives of each compound support the in silico predictions.

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