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Original Research
Hoë voorkomskoers van bakteriële vaginose en Chlamydia in ’n lae-inkomste, hoë-bevolkingsdigtheid gemeenskap in Kaapstad
Submitted: 22 November 2017 | Published: 12 December 2017
About the author(s)
Katie S. Lennard, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Computational Biology Division, University of Cape Town, South Africa; Department of Integrative Biomedical Sciences, University of Cape Town, South AfricaSmritee Dabee, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Department of Pathology, University of Cape Town, South Africa
Shaun L. Barnabas, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Department of Pathology, University of Cape Town, South Africa
Enock Havyarimana, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Department of Pathology, University of Cape Town, South Africa
Shameem Z. Jaumdally, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Department of Pathology, University of Cape Town, South Africa
Gerrit Botha, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Computational Biology Division, University of Cape Town, South Africa; Department of Integrative Biomedical Sciences, University of Cape Town, South Africa
Nonhlanhla N. Mkhize, National Health Laboratory Service, South Africa
Linda-Gail Bekker, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Desmond Tutu HIV Centre, University of Cape Town, South Africa
Glenda Gray, Perinatal HIV Research Unit, University of the Witwatersrand, South Africa; South African Medical Research Council, South Africa
Nicola Mulder, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Computational Biology Division, University of Cape Town, South Africa; Department of Integrative Biomedical Sciences, University of Cape Town, South Africa
Jo-Ann Passmore, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Department of Pathology, University of Cape Town, South Africa; National Health Laboratory Service, South Africa
Heather B. Jaspan, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Department of Pathology, University of Cape Town, South Africa; Seattle Children’s Research Institute, Department of Pediatrics and Global Health, University of Washington, United States
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Abstract
Jong Suid-Afrikaanse vroue uit hulpbron-arm gemeenskappe staar verskeie uitdagings in die gesig in terme van hulle seksuele en reproduktiewe gesondheid. Hier beskryf ons die voorkoms van vaginale mikrobiota en seksueel oordraagbare infeksies (SOI’s) onder 102; 16–22-jarige MIV-negatiewe Suid-Afrikaanse vroue uit ’n lae-inkomste, hoë-bevolkingsdigtheid gemeenskap in Kaapstad. Vaginale mikrobiota is met behulp van 16S rRNA amplikon volgorde-bepaling geprofileer; bakteriese vaginose (BV) status is met behulp van ’n Nugent-telling vasgestel; en SOI’s is deur middel van ’n multipleks polimerase kettingreaksie bepaal. SOI’s was algemeen, met 55% van die vroue wat ten minste een SOI gehad het; 41% wat met hoë-risiko menslike papillomavirus (MPV) besmet was, en ’n verdere 28% wat met laerisiko-MPV besmet was; 44% van die vroue was met Chlamydia besmet waarvan 16% een of meer addisionele SOI gehad het. BV persentasies was ook baie hoog met 55% van die vroue wat as BV-positief (Nugent-telling ≥7) geklassifiseer is, 7% as BV-intermediêr (Nugent-telling 3–6), en 38% as BV-negatief (Nugent-telling 0–2). Streptococcus (Streptococcus agalactiae), die grootste oorsaak van neonatale sepsis, was teenwoordig in 25% van die BV-positiewe vroue en 28% van die BV-negatiewe vroue, en was dus meer onder BV-negatiewe vroue. Chlamydia-infeksie sowel as BV kan reproduktiewe gesondheid nadelig beïnvloed en verhoog hierdie vroue se risiko vir die verkryging van MIV. Die voorkoms van veral Prevotella amnii kan die MIV-risiko verhoog as gevolg van sy inflammatoriese kapasiteit. Laboratorium-gebaseerde toetsing vir SOI’s (veral Chlamydia en Gonorrhoeae) blyk in hierdie gemeenskap geregverdig te wees, tesame met verdere monitering en/of behandeling van BV.
Navorsing korrelasie: Hierdie artikel is die vertaalde weergawe en is beskikbaar gestel om ‘n breër lesersgroep te bereik. Die oorspronklike Engelse artikel is beskikbaar hier: https://doi.org/10.4102/satnt.v36i1.1484
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