Conference Abstract: Annual Congress of the Biological Sciences Division 2013

Combination of glucose transporter inhibitors and oestrone analogues on breast cancer cells

A. van Tonder, A.J. Joubert, A.D. Cromarty
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie | Vol 33, No 1 | a1263 | DOI: https://doi.org/10.4102/satnt.v33i1.1263 | © 2014 A. van Tonder, A.J. Joubert, A.D. Cromarty | This work is licensed under CC Attribution 4.0
Submitted: 12 September 2014 | Published: 07 October 2014

About the author(s)

A. van Tonder, Department of Pharmacology, University of Pretoria, South Africa
A.J. Joubert, Department of Physiology, University of Pretoria, South Africa
A.D. Cromarty, Department of Pharmacology, University of Pretoria, South Africa


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Abstract

Combinations of chemotherapeutic agents are commonly used in the clinical setting as this allows for a reduction in the dose of each agent, and thus reduced toxicity, with increased therapeutic efficacy. This study proved the feasibility of synergy between two novel oestrone analogues and GLUT inhibitors. The synergistic combinations which have been identified indicate that the different molecular subtypes of breast cancer, as represented by the cell lines used, respond differently to the combination therapy. These differences will be further investigated.

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